Figure 7 | Scientific Reports

Figure 7

From: Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage

Figure 7

NRAS over-expression weakened DHA-introduced DNA damage of lung cancer cells. A549 and LLC were transfected by NRAS plasmid first, and then incubated with DHA (60 μg/ml). (A–B) The expression of NRAS and p-ERK1/2 in A549 and LLC was measured with WB. (C–D) WB revealed that over-expression with NRAS plasmid reduced DNA damage induced by DHA. (E–L) The mean gray of bands was quantitatively analyzed and presented. (M–N) Comet experiments suggested that NRAS plasmid recovery impaired DHA-triggered DNA double-strand breakage. Values were means ± SD (n = 3, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).

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