Figure 4
From: Short- and long-term outcomes of pulmonary exposure to a sublethal dose of ricin in mice
Collagen deposition in the lungs of mice following sublethal ricin intoxication. Mice were intranasally intoxicated with (1.7 µg/kg body weight) ricin, lungs were harvested at day 6 or 30 following exposure and Masson’s Trichrome staining was conducted on paraffin-embedded sections. Collagen deposition and fibrous connective tissue indicated in blue. (A–C) normal lung architecture in sham control lung intranasally exposed to PBS. (D–F) Lung sections from mice 6 days following ricin exposure. (G–I) Lung sections from mice 30 days following ricin exposure. (A,D,G) Low magnification (×2) of a lung lobes. (B,E,H) Bronchioles and blood vessel areas. (C,F,I) Alveoli. Black arrows indicate the presented lesions. Panels are representatives of 5 mice in each group, scale bar: 500 µm (A,D,G); 50 µm (B,C,E,F,H,I).
