Figure 5 | Scientific Reports

Figure 5

From: Comprehensive data mining reveals RTK/RAS signaling pathway as a promoter of prostate cancer lineage plasticity through transcription factors and CNV

Figure 5

Analysis results of the expression, CNVs, and transcription factor activity of the 19 leading edge genes in RTK/RAS signaling pathway. (A) The RTK/RAS signaling pathway is positively enriched in high lineage plasticity score samples of prostate cancer. (B) Upregulation of the 19 leading edge genes in prostate cancer RNA-seq data from the TCGA database. (C) The expression of 19 leading-edge genes in prostate cancer single-cell RNA-seq data, with the x-axis and y-axis representing t-SNE1 and t-SNE2, respectively. (D) Copy number variations of the 19 leading edge genes in the TCGA prostate cancer cohort (right) and the SU2C prostate cancer cohort (left). (E) The transcription factors that top enrichment leading edge genes in the GPSAdb database. (F) Transcription factors have transcription active in prostate cancer.

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