Figure 8 | Scientific Reports

Figure 8

From: Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells

Figure 8

PDK4 upregulation in TAZ-KO cells exacerbates AMPK activation and FOXO1 expression. Phosphorylation of AMPK residue Thr172 (p-AMPK) and FOXO1 protein levels were assayed in WT and TAZ-KO myoblasts treated with PDK4-targeted siRNA. The data points represent means ± S.D. (error bars) for each individual biological replicate of each group. * 0.05 < p < 0.1, *** 0.001 < p < 0.01.

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