Table 1 Table shows the treatment effect as the tumor volume for a treatment relative to the tumor volume of a reference treatment, averaged over a time period (Eq. 1).

Tumor cell line	Dose	Days	aPDL1 vs PBS		Proton vs X-rays
Tumor cell line	Dose	Days	Xray	Proton	PBS	aPDL1
MOC1	0	10–19	0.80 ± 0.07**
	5	10–19	0.82 ± 0.08*	0.80 ± 0.09*	1.00 ± 0.11	0.96 ± 0.16
	10	20–29	0.61 ± 0.11**	0.72 ± 0.10*	0.85 ± 0.11	1.01 ± 0.19
	15	20–29	0.32 ± 0.06**	0.50 ± 0.09**	1.28 ± 0.21	2.03 ± 0.43**
	20	20–29	0.62 ± 0.14*	0.61 ± 0.14**	1.32 ± 0.24	1.30 ± 0.34
MOC2	0	5–9	1.11 ± 0.09
	10	10–14	0.78 ± 0.10*	0.81 ± 0.10*	0.91 ± 0.12	0.93 ± 0.14
	20	10–14	0.84 ± 0.13	0.77 ± 0.17	0.87 ± 0.11	0.81 ± 0.20
	30	10–14	0.97 ± 0.14	0.89 ± 0.19	0.73 ± 0.11**	0.67 ± 0.13**

Uncertainties are given as 95% confidence intervals. Reference treatments are PBS or X-rays. p-values were calculated as Fishers combined probability test (within a time period) where individual p-values for each time point used in the calculation were found by paired t-test. p-values < .05 are marked with * and p-values < .01 are marked with **.

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