Table 3 Prediction of pathogenicity of missense SNPs in MCM6 protein as predicted by MutPred2.

1

I123S

0.937

Gain of Intrinsic disorder

0.02

Gain of Allosteric site at R124

0.01

Altered Transmembrane protein

0.02

2

R207C

0.883

Altered Ordered interface

0.02

Altered Metal binding

0.04

Loss of Acetylation at K205

0.04

3

R222C

0.915

Loss of Allosteric site at R222

0.0009

Altered Ordered interface

0.0081

Gain of Loop

0.0022

4

V456M

0.872

Altered Metal binding

0.0034

Altered Ordered interface

0.04

Loss of Relative solvent accessibility

0.03

Loss of Allosteric site at E461

0.01

Loss of Catalytic site at E461

0.01

Altered Transmembrane protein

0.01

5

D463G

0.938

Altered Metal binding

0.00021

Altered Ordered interface

0.05

Loss of Allosteric site at D463

0.0075

Loss of Relative solvent accessibility

0.03

Gain of Catalytic site at E461

0.0066

Gain of Acetylation at K464

0.03

6

R602H

0.892

Loss of Acetylation at K599

0.03

Altered Disordered interface

0.04

Altered DNA binding

0.03

7

R633W

0.876

Altered Metal binding

0.05

Gain of Allosteric site at E629

0.03

8

R658C

0.842

Loss of Phosphorylation at T661

0.02

Gain of Loop

0.03

Loss of Acetylation at K654

0.0079

Loss of ADP-ribosylation at R658

0.05

Altered Transmembrane protein

0.0077