Figure 7
From: Anxiolytic effects of Enterococcus faecalis 2001 on a mouse model of colitis
Effects of EF-2001 on NMDAR signaling and synaptic plasticity-related proteins in the PFC. Effects of chronic treatment with Enterococcus faecalis 2001 (EF-2001) on the NMDA receptor subunits (NRs), CAMKII/CREB/BDNF pathway, and synaptic plasticity-related proteins. a-l: Quantification of the normalized values of NR1 (a), NR2A (b), NR2B (c), BDNF (f), synaptophysin (g), SNAP25 (h), PSD95 (i), drebrin (j), MAP2 (k), and NeuN (l) levels with β-actin and p-CAMKII (d) and p-CREB (e) with t-CAMKII and t-CREB, respectively. Original immunoblot images were shown in Supplementary Fig. S4. (m) and (n) Microscopy images of NeuN (red), DAPI (blue), and p-CAMKII (m) or p-CREB (n) (green) immunostaining in the PFC of DSS mice treated with EF-2001. Bars represent means ± standard error of mean (SEM). *p < 0.05 and **p < 0.01 vs. water-treated water group, #p < 0.05 and ##p < 0.01 vs. water-treated DSS group (n = 6 per group).
