Figure 3 | Scientific Reports

Figure 3

From: Active juvenile systemic lupus erythematosus is associated with distinct NK cell transcriptional and phenotypic alterations

Figure 3

Increased frequencies of NK cells expressing activation markers in JSLE. Boxplots showing frequencies of (a) CD25+ (b) NKg2D+ (c) CD69+ (d) CD107a+ NK cells (HC n = 8, JSLE n = 9), with and without IL-2 and IL-15 stimulation. Box plots shown median ± IQR. p-values calculated using paired or unpaired t-tests or Mann–Whitney U tests. (e) Cytotoxicity of NK cells from healthy controls and JSLE patients against K562 cells at increasing effector:target (E:T) ratios measured in a 4-h flow cytometry assay. (f) Bar plot quantifying NK cytotoxicity against K562 cells at 5:1 E:T ratio. p-value calculated using two-sided Student’s t-test.

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