Figure 3 | Scientific Reports

Figure 3

From: Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients

Figure 3

FMT-responsive patients exhibit sustained microbiota differences that are sustained post-treatment. (A) Faith’s phylogenetic diversity is displayed for each time point in non-responders (orange), responders (blue), and donors (green). (B) Axis 1 (Unweighted UniFrac) is displayed for each time point in non-responders, responders, and donors. Pairwise comparisons between non-responders and responders were performed using a Wilcoxon rank sum test (*p < 0.1; **p < 0.05). For both (A) and (B), the mean value of Faith’s phylogenetic diversity and Axis 1 was computed for a total of 48 samples from donor 1, 6 samples from donor 2, and 11 samples from donor 3. (C) Using patient samples at all follow-up time points and donors, beta diversity (Unweighted UniFrac) was compared between non-responders, responders, and donors using a linear mixed effects model. (D) Volcano plot of differentially abundant species (DESeq2; FDR-adjusted p < 0.05); colors indicate species and shapes indicate follow-up time points 1, 2, and 3. “NA” indicates species that were not significantly different. ABX, antibiotic; FMT, fecal microbial transplantation; F/u, follow-up.

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