Figure 5 | Scientific Reports

Figure 5

From: Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients

Figure 5

Loss of microbes with the capacity to produce hypotaurine and taurine associates with FMT responsiveness. Integration of fecal shotgun metagenomic (HumaNn3) and metabolomic datasets (Metabolon) was performed using MIMOSA2 and identified (A) hypotaurine and (B) taurine as fecal microbiome-derived metabolites. Microbial producers of both metabolites are shown in Table S6. (C,D) Normalized abundance levels for each metabolite are displayed for non-responders and responders at the first and second follow-up time points. Comparisons between non-responders and responders were performed using a one-sided Wilcoxon rank-sum test. (E) From the IBDMD cohort, log-transformed abundance levels for taurine are shown by ulcerative colitis severity groups, as defined by SCCAI categories. An association between metabolite abundance levels and SCCAI categories were tested using an ordinal logistic regression. See Table S6 for the microbial species and their genes that metabolize hypotaurine and taurine. CMP; community metabolic potential score.

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