Figure 7 | Scientific Reports

Figure 7

From: Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation

Figure 7

Gene expression pattern in D-HCM iPSC-CMs. (A). GSEA analysis using Gene Ontology (GO). Top-ranked gene set lists were arranged in each table (p < 0.05 and low FDR rank). Ctrl: N = 4 from 2 cell lines, D-HCM: N = 5 from 1 cell line. (B). Graphs of the top two gene sets in GO. (C). Heatmap of mitochondrial electron transport-related genes. (D). mRNA expression levels of mitochondrial electron transport-related genes: NDUFB1, COX5B, UQCRB and ATPIF1 by RT-qPCR. n.s. indicates not significant vs. Ctrl; *p < 0.05 vs. Ctrl; **p < 0.01 vs. Ctrl.

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