Figure 1
From: Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice
Podocyte-specific deletion of IRE1α exacerbates albuminuria in diabetic nephropathy. Induction of diabetes with STZ resulted in progressive albuminuria in IRE1α KO mice. N = 4 mice in control (Ctrl) untreated (Untr), 9 in KO Untr, 7 in Ctrl STZ and 13 in KO STZ groups. In the KO STZ group, 2 animals died prior to 6 months and are included until the time-points of death. In the other 3 groups, data on all animals are up to 6 months. Data were analyzed with a 2-way ANOVA. When the 1–6 month time points are considered together, significant changes are: P < 0.01 Ctrl STZ vs KO STZ and P < 0.0001 KO Untr vs KO STZ. Ctrl Untr vs Ctrl STZ did not reach statistical significance. *P < 0.05, ***P < 0.001, ****P < 0.0001.
