Table 10 Relative expression of PPAR-γ genes in cortex and hippocampus of different experimental rats.

From: Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway

Groups

Parameters

Relative expression of PPARγ (Fold-change)

Cortex

Hippocampus

Normal

4.03b ± 0.11

5.23b ± 0.37

Free NAR (50 mg/kg)

3.38b ± 0.18

4.96b ± 0.10

NAR- HNPs (50 mg/kg)

3.53b ± 0.20

4.77b ± 0.11

Control STZ (50 mg/kg)

1.01acd ± 0.09

1.03acd ± 0.17

STZ + unloaded HNPs

1.39acd ± 0.20

1.38acd ± 0.22

STZ + NAR (50 mg/kg)

2.63ab ± 0.02

4.83b ± 0.31

STZ + NAR-HNPs (50 mg/kg)

2.57ab ± 0.08

4.62b ± 0.18

STZ + NAR (50 mg/kg) + GW9662

1.32acd ± 0.11

1.34acd ± 0.18

  1. The mRNA expression PPAR-γ is normalized with housekeeping gene (GAPDH), values are stated as means ± SEM, n = 3 per group (all samples run in duplicate and no template control were included in all runs). a vs normal group, b vs control STZ group, c vs STZ + NAR (50 mg/kg), d vs STZ + NAR-HNPs (50 mg/kg) at p < 0.05. NAR, naringenin; STZ, streptozotocin; NAR-HNPs, naringenin- loaded hybridized nanoparticles.