Table 6 Pharmacokinetic parameters of NAR and NAR-HNPs in normal rats.
Treatment | Parameters | ||||||||
|---|---|---|---|---|---|---|---|---|---|
t ½ (h) | λz (h−1) | C max (µg/ml) | T max (h) | AUC 0-∞ (µg ml h−1) | MRT (h) | AUMC 0-∞ (µg ml h−1) | Vz/F (mg/kg) (µg/ml) | CL/F (mg/kg) (µg/ml) | |
NAR (50 mg/kg) | 4.496 ± 0.207 | 0.154 ± 0.007 | 0.504 ± 0.026 | 4 ± 0.0 | 4.569 ± 0.217 | 8.326 ± 0.272 | 38.15 ± 0.287 | 71.12 ± 3.202 | 10.97 ± 0.555 |
NAR-HNPs (50 mg/kg) | 10.26* ± 1.21 | 0.695* ± 0.009 | 0.670 ± 0.067 | 4 ± 0.0 | 6.897* ± 0.281 | 15.56* ± 1.784 | 108.3* ± 15.91 | 106.6* ± 9.15 | 7.268* ± 0.3028 |
