Table 8 Effect of NAR and NAR-HNPs on cortical monoamines and metabolites in experimental rats.
Groups | Parameters | ||||
|---|---|---|---|---|---|
Cortex (μg/g) | |||||
NE | 5-HT | 5-HTAA | DA | DOPAC | |
Normal | 0.34b ± 0.01 | 0.40b ± 0.05 | 0.07b ± 0.00 | 0.63b ± 0.01 | 0.10b ± 0.00 |
Free NAR | 0.36b ± 0.03 | 0.37b ± 0.02 | 0.07b ± 0.00 | 0.58b ± 0.02 | 0.10b ± 0.01 |
NAR-HNPs | 0.31b ± 0.02 | 0.36b ± 0.03 | 0.07b ± 0.00 | 0.55b ± 0.01 | 0.10b ± 0.00 |
Control STZ | 0.18acd ± 0.01 | 0.26 acd ± 0.01 | 0.09 acd ± 0.00 | 0.43 acd ± 0.02 | 0.13 acd ± 0.01 |
STZ + unloaded HNPs | 0.18 acd ± 0.01 | 0.27 acd ± 0.03 | 0.10 acd ± 0.01 | 0.42 acd ± 0.04 | 0.13 acd ± 0.01 |
STZ + NAR (50 mg/kg) | 0.25abd ± 0.02 | 0.37b ± 0.03 | 0.07 bd ± 0.00 | 0.57 bd ± 0.04 | 0.11bd ± 0.00 |
STZ + NAR-HNPs (50 mg/kg) | 0.37bc ± 0.01 | 0.44b ± 0.01 | 0.08 bc ± 0.00 | 0.68bc ± 0.04 | 0.10 bc ± 0.00 |
STZ + NAR (50 mg/kg) + GW9662 | 0.18acd ± 0.00 | 0.27 acd ± 0.00 | 0.09 acd ± 0.01 | 0.41acd ± 0.01 | 0.14 acd ± 0.00 |
