Scientific Reports

Table 9 Effect of NAR and NAR-HNPs on hippocampal monoamines and metabolites in experimental rats.

From: Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway

Groups	Parameters
	Hippocampus (μg/g)
	NE	5-HT	5-HTAA	DA	DOPAC
Normal	0.62^b ± 0.02	0.62^b ± 0.05	0.13^b ± 0.01	1.50^b ± 0.05	0.26^b ± 0.02
Free NAR	0.60^b ± 0.01	0.62^b ± 0.06	0.15^b ± 0.01	1.35^b ± 0.02	0.25^b ± 0.00
NAR-HNPs	0.57^b ± 0.02	0.71^b ± 0.07	0.14^b ± 0.00	1.53^b ± 0.07	0.26^b ± 0.02
Control STZ	0.43^acd ± 0.02	0.36 ^acd ± 0.01	0.20 ^acd ± 0.00	1.00 ^acd ± 0.07	0.35 ^acd ± 0.01
STZ + unloaded HNPs	0.40 ^acd ± 0.02	0.40 ^acd ± 0.03	0.19 ^acd ± 0.01	1.09 ^acd ± 0.01	0.34 ^acd ± 0.00
STZ + NAR (50 mg/kg)	0.53^abd ± 0.00	0.54 ^bd ± 0.01	0.17 ^abd ± 0.01	1.32 ^abd ± 0.05	0.27^bd ± 0.02
STZ + NAR-HNPs (50 mg/kg)	0.62^bc ± 0.01	0.70 ^bc ± 0.02	0.14^bc ± 0.01	1.70^abc ± 0.10	0.23 ^bc ± 0.01
STZ + NAR (50 mg/kg) + GW9662	0.43 ^acd ± 0.01	0.39 ^acd ± 0.01	0.20 ^acd ± 0.01	1.04 ^acd ± 0.08	0.34 ^acd ± 0.01

Results are stated as means ± SEM (n = 6), ^a vs normal group, ^b vs control STZ group, ^c vs STZ + NAR (50 mg/kg), ^d vs STZ + NAR-HNPs (50 mg/kg) at p < 0.05. NAR, naringenin; STZ, streptozotocin; NAR-HNPs, naringenin- loaded hybridized nanoparticles.

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