Figure 4 | Scientific Reports

Figure 4

From: Extracellular vesicles from GABAergic but not glutamatergic neurons protect against neurological dysfunction following cranial irradiation

Figure 4

Treatment with GABAergic extracellular vesicles (EVs) improves cognitive performance. (A) Novel Object, (B) Novel Place, and (C) Object in Place Recognition performance following irradiation. Animals were treated with GABAergic or glutamatergic neuron derived EVs following fractionated irradiation (left and right panels, respectively). Radiation-induced decrements in performance on these tasks are not mitigated by glutamatergic EVs. Data are presented as the mean ± SEM (N = 16 animals/group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; one-way ANOVA with Bonferroni’s multiple comparisons test.

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