Figure 5 | Scientific Reports

Figure 5

From: Extracellular vesicles from GABAergic but not glutamatergic neurons protect against neurological dysfunction following cranial irradiation

Figure 5

Radiation-induced reduction in neurotrophic factors is ameliorated by GABAergic and glutamatergic extracellular vesicles (EVs). (A,B) Levels of brain-derived neurotrophic factor (BDNF) are significantly decreased following irradiation (IRR) compared to controls. Treatment with (A) GABAergic (left panel) and glutamatergic (right panel) neuron derived EVs rescued BDNF levels to near that of controls. (B) Levels of glial cell-derived neurotrophic factor (GDNF) are significantly reduced upon IRR and treatment with GABAergic (left panel) and glutamatergic (right panel) neuron derived EVs significantly increase GDNF. Data are presented as the mean ± SEM (N = 4–5 animals/group). *P < 0.05; **P < 0.01, ***P < 0.001, ****P < 0.0001; one-way ANOVA with Bonferroni’s multiple comparisons test.

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