Figure 6
From: Reliable anti-cancer drug sensitivity prediction and prioritization
Prioritization results across all test cell lines of GDSC2. In A, we show the classification performance of SAURON-RF with and without our CP pipeline. B depicts the regression performance in terms of MSE, PCC and SCC. Here, the MSE is given for the effective drugs, the ineffective drugs, and all drugs. We provide the SCC for the predicted values using SAURON-RF only (SCC) and the upper limit of the CP interval (SCC upper lim.). In C, we plot various measures to evaluate our prioritized drug lists. The upper row of C depicts the precision of SAURON-RF without (SAURON-RF class + SAURON-RF continuous prediction) and with CP (TC + upper limit, Mon + upper limit, Sum + upper limit). In the middle row, we show the percentage of cell lines for which the most efficient drug was detected, the median rank of the first drug in our effective drug list and the percentage of cell lines for which this prediction was a TP. The CMax viability difference between our first drug and the actual first drug is depicted in the lower row.
