Table 1 Patients’ clinicopathological features stratified by right and left colon.
From: Prognostic factors and survival disparities in right-sided versus left-sided colon cancer
Variables | RCC (n = 1453, 58.7%) | LCC (n = 1022, 41.3%) | P-value |
|---|---|---|---|
Sex | < 0.001 | ||
M | 637 (43.8) | 540 (52.8) | |
F | 816 (56.2) | 482 (47.2) | |
Age (years) | < 0.001 | ||
< 50 | 74 (5.1) | 145 (14.2) | |
50–75 | 669 (46.0) | 552 (54.0) | |
75 + | 710 (48.9) | 325 (31.8) | |
BMI (kg/m2) | 0.860 | ||
< 18.5 | 32 (2.4) | 26 (2.8) | |
18.6–25 | 568 (42.0) | 384 (40.6) | |
25.1–30 | 471 (34.9) | 334 (35.3) | |
30.1 + | 280 (20.7) | 202 (21.4) | |
ASA score | < 0.001 | ||
1 | 173 (11.9) | 218 (21.3) | |
2 | 525 (36.1) | 377 (36.9) | |
3 | 641 (44.1) | 363 (35.5) | |
4 | 114 (7.9) | 64 (6.3) | |
History of smoking (yes) | 628 (43.2) | 469 (45.9) | 0.189 |
Current smoker (yes) | 76 (5.2) | 72 (7.1) | 0.070 |
IBD (yes) | 31 (2.1) | 12 (1.2) | 0.085 |
PVD (yes) | 81 (5.6) | 41 (4.0) | 0.089 |
Hypertension (yes) | 783 (53.9) | 457 (44.7) | < 0.001 |
IHD (yes) | 404 (27.8) | 206 (20.2) | < 0.001 |
MI (yes) | 98 (6.7) | 56 (5.5) | 0.206 |
CHF (yes) | 87 (6.0) | 45 (4.4) | 0.085 |
CVA (yes) | 114 (7.9) | 57 (5.6) | 0.030 |
Diabetes (yes) | 243 (16.7) | 160 (15.7) | 0.507 |
Screen detected (yes) | 179 (12.3) | 171 (16.7) | 0.002 |
Operative urgency | 0.098 | ||
Emergency | 71 (4.9) | 71 (7.0) | |
Urgent | 133 (9.2) | 93 (9.1) | |
Elective | 1242 (85.9) | 854 (83.9) | |
Anastomosis formed (yes) | 1395 (96.5) | 900 (88.4) | < 0.001 |
Stoma formed (yes) | 51 (3.5) | 173 (16.9) | < 0.001 |
Organs resected (yes) | 95 (6.6) | 103 (10.1) | 0.002 |
Tumour type | < 0.001 | ||
Adenocarcinoma | 1135 (78.1) | 855 (83.7) | |
Adenocarcinoma mucinous | 235 (16.2) | 70 (6.9) | |
Adenocarcinoma signet | 22 (1.5) | 3 (0.3) | |
No residual | 61 (4.2) | 94 (9.2) | |
Grade | < 0.001 | ||
Undifferentiated | 5 (0.4) | 4 (0.4) | |
Poor | 402 (28.5) | 127 (13.3) | |
Moderate | 934 (66.3) | 782 (81.9) | |
Well | 68 (4.8) | 42 (4.4) | |
Lymph node yield | < 0.001 | ||
< 12 | 216 (15.1) | 229 (22.6) | |
12 + | 1219 (85.0) | 784 (77.4) | |
Positive nodes (yes) | 527 (36.3) | 404 (39.5) | 0.101 |
Lymph node ratio | 0.271 | ||
0 to < 0.0825 | 1083 (75.6) | 745 (73.6) | |
0.0825 to < 0.25 | 206 (14.4) | 167 (16.5) | |
0.25 to < 0.5 | 91 (6.4) | 72 (7.1) | |
0.5 to 1 | 52 (3.6) | 28 (2.8) | |
Lymphovascular invasion (yes) | 551 (37.9) | 354 (34.6) | 0.098 |
Circumferential margins | > 0.999 | ||
Negative | 1437 (98.9) | 1011 (98.9) | |
Positive | 16 (1.1) | 11 (1.1) | |
IHC results | < 0.001 | ||
pMMR | 568 (60.8) | 559 (93.2) | |
dMMR | 366 (39.2) | 41 (6.8) | |
T stage | 0.189 | ||
0 | 4 (0.3) | 3 (0.3) | |
1 | 184 (12.7) | 166 (16.2) | |
2 | 227 (15.6) | 142 (13.9) | |
3 | 753 (51.8) | 518 (50.7) | |
4 | 271 (18.7) | 181 (17.7) | |
NR | 14 (1.0) | 12 (1.2) | |
N stage | 0.181 | ||
0 | 901 (62.1) | 596 (58.3) | |
1 | 339 (23.4) | 275 (26.9) | |
2 | 194 (13.4) | 141 (13.8) | |
NR | 18 (1.2) | 10 (1.0) | |
M stage | 0.281 | ||
0 | 1161 (80.0) | 800 (78.4) | |
1 | 168 (11.6) | 140 (13.7) | |
NR | 122 (8.4) | 81 (7.9) | |
Overall stage | 0.005 | ||
1 | 349 (24.2) | 261 (25.8) | |
2 | 529 (36.7) | 303 (29.9) | |
3 | 396 (27.5) | 309 (30.5) | |
4 | 168 (11.7) | 140 (13.8) | |
Surgical complications (yes) | 244 (16.8) | 167 (16.3) | 0.748 |
Medical complications (yes) | 147 (10.1) | 96 (9.4) | 0.583 |
Any complications (yes) | 345 (23.7) | 236 (23.1) | 0.736 |
Returned to theatre (yes) | 75 (5.2) | 70 (6.9) | 0.083 |
Length of stay | 0.287 | ||
< 5 days | 394 (27.2) | 313 (30.6) | |
5–7 days | 330 (22.8) | 217 (21.2) | |
7–12 days | 371 (25.6) | 258 (25.2) | |
> 12 days | 355 (24.5) | 234 (22.9) | |
Chemotherapy (received) | 382 (26.3) | 356 (34.8) | < 0.001 |
30-day mortality (yes) | 9 (0.6) | 9 (0.9) | 0.478 |
