Table 3 Univariable and multivariable Bayesian log-logistic AFT regression model of factors affecting overall and relapse-free survival.

From: Prognostic factors and survival disparities in right-sided versus left-sided colon cancer

Variables

Univariable

Multivariable

OS TR (95% CI)

RFS TR (95% CI)

OS TR (95% CI)

RFS TR (95% CI)

Colon

 Right

Reference

Reference

Reference

Reference

 Left

1.41 (1.15–1.69)*

1.42 (1.10–1.75)*

1.17 (0.95–1.43)

1.19 (0.95–1.48)

Sex

 M

Reference

Reference

Reference

Reference

 F

1.11 (0.92–1.33)

1.15 (0.88–1.40)

1.10 (0.93–1.32)

1.02 (0.85–1.21)

Age (years)

 < 50

Reference

Reference

Reference

Reference

 50–75

1.14 (0.76–1.55)

1.26 (0.69–1.84)

1.03 (0.77–1.23)

1.36 (1.02–1.75)

 75 + 

0.52 (0.34–0.70)

0.54 (0.31–0.78)

0.72 (0.56–0.90)

0.79 (0.65–0.94)

BMI (kg/m2)

 18.6–25

Reference

Reference

Reference

Reference

 < 18.5

0.47 (0.25–0.70)*

0.45 (0.23–0.68)*

0.81 (0.58–1.06)

0.87 (0.64–1.12)

 25.1–30

1.37 (1.08–1.67)*

1.38 (1.07–1.70)*

1.59 (1.28–1.90)*

1.50 (1.18–1.77)*

 30.1 + 

1.21 (0.95–1.51)

1.22 (0.94–1.52)

1.85 (1.43–2.30)*

1.62 (1.31–1.93)*

ASA score

 1

Reference

Reference

Reference

Reference

 2

0.46 (0.33–0.63)*

0.39 (0.24–0.56)*

0.52 (0.47–0.58)*

0.43 (0.37–0.51)*

 3

0.28 (0.19–0.38)*

0.23 (0.14–0.33)*

0.37 (0.29–0.46)*

0.28 (0.24–0.33)*

 4

0.10 (0.07–0.15)*

0.07 (0.04–0.11)*

0.36 (0.27–0.46)*

0.21 (0.16–0.26)*

History of smoking (yes)

1.02 (0.81–1.20)

1.01 (0.78–1.24)

1.07 (0.90–1.27)

1.03 (0.81–1.28)

Current smoker (yes)

1.11 (0.70–1.57)

1.14 (0.61–1.71)

0.90 (0.59–1.25)

0.98 (0.60–1.44)

IBD (yes)

0.74 (0.33–1.28)

0.75 (0.23–1.39)

1.03 (0.64–1.44)

1.24 (0.53–2.17)

PVD (yes)

0.64 (0.41–0.89)*

0.67 (0.39–0.98)*

0.75 (0.47–1.07)

0.70 (0.39–1.07)

Hypertension (yes)

0.83 (0.68–0.98)*

0.88 (0.67–1.07)

0.95 (0.74–1.16)

0.96 (0.78–1.15)

IHD (yes)

0.65 (0.52–0.79)*

0.63 (0.48–0.81)*

0.75 (0.56–0.91)*

0.85 (0.66–1.08)

MI (yes)

0.69 (0.47–0.96)*

0.70 (0.43–1.02)

0.86 (0.57–1.13)

0.97 (0.51–1.44)

CHF (yes)

0.49 (0.32–0.69)*

0.50 (0.28–0.73)*

0.90 (0.58–1.18)

0.87 (0.54–1.21)

CVA (yes)

0.73 (0.51–1.02)

0.75 (0.46–1.07)

0.75 (0.59–0.94)*

0.90 (0.52–1.40)

Diabetes (yes)

0.87 (0.67–1.09)

0.82 (0.59–1.07)

1.25 (0.99–1.53)

1.18 (0.88–1.49)

Screen detected (yes)

2.89 (1.74–4.11)*

3.84 (2.12–5.86)*

1.22 (1.02–1.48)*

1.48 (1.08–1.86)*

Operative urgency

 Elective

Reference

Reference

Reference

Reference

 Emergency

0.25 (0.17–0.34)*

0.24 (0.16–0.32)*

1.03 (0.87–1.17)

0.99 (0.82–1.14)

 Urgent

0.33 (0.24–0.43)*

0.32 (0.23–0.41)*

1.00 (0.76–1.27)

0.97 (0.76–1.23)

 Anastomosis formed (yes)

3.29 (2.31–4.50)*

4.17 (2.65–5.87)*

1.47 (1.11–1.82)*

1.05 (0.77–1.34)

 Stoma formed (yes)

0.45 (0.33–0.58)*

0.35 (0.23–0.49)*

1.22 (0.99–1.45)

0.82 (0.62–1.01)

 Organs resected (yes)

0.34 (0.25–0.45)*

0.25 (0.16–0.33)*

0.70 (0.53–0.85)*

0.69 (0.55–0.81)*

Tumour type

 Adenocarcinoma

Reference

Reference

Reference

Reference

 Adenocarcinoma mucinous

1.10 (0.81–1.43)

1.19 (0.84–1.64)

1.05 (0.87–1.27)

1.11 (0.94–1.29)

 Adenocarcinoma signet

0.20 (0.08–0.34)*

0.14 (0.04–0.27)*

0.47 (0.30–0.63)*

0.69 (0.44–0.96)

 No residual

4.33 (1.81–7.25)*

6.68 (2.10–12.68)*

–

–

Grade

 Well

Reference

Reference

Reference

Reference

 Undifferentiated

0.54 (0.02–1.55)

0.60 (0.01–1.91)

1.08 (0.75–1.39)

0.99 (0.82–1.18)

 Poor

0.21 (0.09–0.35)*

0.15 (0.05–0.28)*

0.39 (0.32–0.46)*

0.32 (0.24–0.39)*

 Moderate

0.47 (0.20–0.76)*

0.39 (0.12–0.69)*

0.61 (0.52–0.70)*

0.63 (0.46–0.84)*

Lymph node yield

 < 12

Reference

Reference

Reference

Reference

 12 + 

1.29 (1.02–1.57)*

1.37 (1.01–1.75)*

1.34 (1.11–1.58)*

1.52 (1.08–1.97)*

Positive nodes (yes)

0.34 (0.27–0.39)*

0.24 (0.19–0.30)*

1.13 (0.85–1.37)

1.06 (0.67–1.44)

Lymph node ratio

 0 to < 0.0825

Reference

Reference

Reference

Reference

 0.0825 to < 0.25

0.43 (0.33–0.52)*

0.35 (0.26–0.45)*

0.64 (0.50–0.75)*

0.71 (0.48–0.94)*

 0.25 to < 0.5

0.20 (0.14–0.26)*

0.12 (0.08–0.16)*

0.36 (0.27–0.44)*

0.37 (0.29–0.47)*

 0.5 to 1

0.12 (0.08–0.16)*

0.07 (0.04–0.10)*

0.27 (0.21–0.34)*

0.20 (0.11–0.31)*

Lymphovascular invasion (yes)

0.35 (0.29–0.42)*

0.27 (0.20–0.32)*

0.80 (0.59–1.04)

0.81 (0.56–1.10)

Circumferential margins

 Negative

Reference

Reference

Reference

Reference

 Positive

0.16 (0.08–0.26)*

0.11 (0.05–0.20)*

1.30 (0.83–1.78)

0.91 (0.43–1.41)

IHC results

 pMMR

Reference

Reference

Reference

Reference

 dMMR

1.20 (0.81–1.65)

1.39 (0.86–1.98)

1.12 (0.91–1.35)

1.26 (0.94–1.59)

T stage

 1

Reference

Reference

—

—

 2

0.76 (0.42–1.09)

0.73 (0.39–1.18)

—

—

 3

0.38 (0.25–0.53)*

0.29 (0.17–0.43)*

—

—

 4

0.11 (0.07–0.16)*

0.06 (0.03–0.10)*

—

—

N stage

 0

Reference

Reference

—

—

 1

0.47 (0.37–0.58)*

0.37 (0.29–0.47)*

—

—

 2

0.19 (0.15–0.24)*

0.12 (0.09–0.15)*

—

—

M stage

 0

Reference

Reference

—

—

 1

0.15 (0.12–0.19)*

0.10 (0.07–0.12)*

—

—

Overall stage

 1

Reference

Reference

Reference

Reference

 2

0.60 (0.42–0.77)*

0.53 (0.35–0.72)*

0.61 (0.48–0.75)*

0.47 (0.39–0.56)*

 3

0.37 (0.26–0.48)*

0.28 (0.19–0.38)*

0.42 (0.34–0.51)*

0.31 (0.25–0.38)*

 4

0.09 (0.06–0.12)*

0.05 (0.03–0.07)*

0.15 (0.13–0.18)*

0.09 (0.06–0.12)*

Surgical complications (yes)

0.66 (0.51–0.82)*

0.62 (0.45–0.80)*

1.06 (0.78–1.37)

1.00 (0.75–1.32)

Medical complications (yes)

0.49 (0.37–0.62)*

0.42 (0.27–0.56)*

0.62 (0.51–0.73)*

0.52 (0.38–0.65)*

Any complications (yes)

0.57 (0.45–0.68)*

0.51 (0.38–0.65)*

1.12 (0.93–1.32)

1.50 (0.98–1.96)

Returned to theatre (yes)

0.70 (0.44–0.98)*

0.69 (0.39–0.99)*

1.09 (0.79–1.39)

1.15 (0.95–1.36)

Length of stay

 < 5 days

Reference

Reference

Reference

Reference

 5–7 days

0.68 (0.48–0.89)*

0.64 (0.42–0.88)*

0.90 (0.63–1.17)

0.83 (0.59–1.09)

 7–12 days

0.43 (0.31–0.55)*

0.36 (0.24–0.48)*

0.73 (0.54–0.95)*

0.69 (0.48–0.91)*

 > 12 days

0.23 (0.17–0.31)*

0.18 (0.12–0.24)*

0.63 (0.47–0.81)*

0.57 (0.35–0.79)

Chemotherapy (received)

0.73 (0.60–0.89)*

0.57 (0.44–0.72)*

1.78 (1.40–2.16)*

1.78 (1.37–2.20)*

  1. TR (95% CI) for significant relationships is shown in bold (*P < 0.05).
  2. AFT Accelerated failure time, OS overall survival, RFS relapse-free survival, TR time ratio, CI highest posterior density credible interval, – not computable due data sparsity, IBD inflammatory bowel disease, PVD peripheral vascular disease, IHD ischemic heart disease, MI myocardial infarction, CHF congestive heart failure, CVA cerebrovascular accident, IHC immunohistochemistry, pMMR proficient mismatch repair, dMMR deficient mismatch repair, BMI body mass index.
  3. —: The T stage, N stage, and M stage have not been included in the model because of their collinearity with the overall stage.
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