Figure 5

Top downregulated and upregulated genes by AmiA peptide ligand. Gene association network of significantly (p value < 0.05) downregulated (log2FC ≤ -2) and upregulated (log2FC ≥ 2) genes in S. pneumoniae strain D39 after 15 min of incubation with AmiA peptide ligand. Lines (edges) represent interactions between 2 genes (nodes) and were imported from the STRING database. Nodes are colour coded according to log2FC expression change: blue represents negative log2FC (downregulated) and red positive log2FC (upregulated). Gene Ontologies or keywords of groups of genes are highlighted in the background.