Table 1 Correlation between tissue gene panel expression levels and clinical characteristics.

Sr. No		n values (%)	CXCL12 (Mean rank values)	p	TGFBR2	p	CD44v6	p	HIF1A	p	KRT7	p
1	Age	33		0.417		0.857		0.259		0.787		0.1074
	> = 59	18	15.72		16.69		15.25		16.56		14.5
	< 59	15	18.53		17.37		19.1		17.53		20
2	Habit			0.096		0.689		0.253		0.0818		0.624
	Smoking	23	18.73		17.44		18.3		15.04		16.43
	Non-smoking	10	12.39		15.83		14		21.5		18.3
3	Differentiation		0.048		0.685		0.671		0.896		0.659
	Poorly diff	12	12.58		16.58		16		16.67		15.91
	Diff unknown	21	19.52		17.24		17.57		17.19		17.55
4	Stage			0.681		0.96		0.008		0.857		0.303
	III	15	17.88		17.14		21.8		16.58		14.81
	IV	18	16.42		16.89		13		17.27		18.42
5	EGFR Status		0.275		0.322		0.427		0.645		1
	Wildtype	12	19.64		14.59		15.21		15.86		17.05
	Mutation	21	15.68		18.2		18.02		17.57		16.98
6	AE1			0.417		0.303		0.899		0.528		0.496
	Positive	13	15.27		19.19		17.31		18.35		18.46
	Negative	20	18.12		15.58		16.8		16.12		16.05
7	Chromogranin		0.818		0.896		0.043		0.802		0.603
	Positive	11	16.56		18.28		13.45		17.47		17.94
	Negative	22	17.41		17.76		20.77		16.56		16.12
8	CEA			0.031		0.96		0.735		0.0093		0.0423
	Positive	15	21		16.87		17.63		21.83		12.64
	Negative	18	13.67		17.11		16.47		12.97		19.5
9	CK20			0.541		0.638		0.696		0.1556		0.483
	Positive	6	14.75		18.75		15.75		22.17		19.58
	Negative	27	17.5		16.61		17.4		15.85		16.43
10	CK7			0.173		1		0.643		0.757		0.152
	Positive	28	17.98		17.02		16.64		17.09		18.04
	Negative	5	11.5		16.9		19		19.9		11.2
11	CDX2			0.218		0.794		0.899		0.332		0.238
	Positive	12	14.62		16.38		17.31		19.21		19.67
	Negative	21	19.02		17.36		16.8		15.74		15.48
12	TTF-1			0.033		0.802		0.708		0.322		0.158
	Positive	15	20.97		17.5		16.3		15.13		14.37
	Negative	18	13.69		16.58		17.58		18.56		19.19

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