Figure 5
From: Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage
Construction of the SAA-target-ICH network and Find the Hub node. (A) Venn diagram showing the overlap of 58 genes between the potential targets of SAA and ICH-related genes. (B) PPI maps revealed the results of PPI network analysis. The larger node size indicates a higher number of protein interactions. (C) GO enrichment and KEGG pathway enrichment of DEGs. (D) The Cytohubba module in the Cytoscape software was used to find the HUB gene. The network interface diagram shows the connection of these HUB genes in the network. The darker the node color is, the higher the score is. (E) Heatmap of the top 10 in network string interactions ranked by degree method. (F) Heatmap of the docking scores of the active compounds of SAA and the target proteins. (G) Molecular docking results of “SAA compound-hub gene.” (a) SAA to AKT1; (b) SAA to PTGS2; (c) SAA to EGFR.
