Figure 2

Fges enrichment scores reveal three subgroups within the PTB cohorts. (A) Hierarchical clustering heatmap illustrating clusters formed based on the ES of 29 Fges across 34 TB cohorts. (B) Stacked bar plot depicting the percentage distribution of three clusters within each TB cohort, with clusters identified by color codes. (C) Scatter plot displaying the distribution of PTB samples using principal component analysis. Each dot represents an individual sample, and clusters are differentiated by color codes. (D) Violin combined with box plot showcasing the signature score of cytokine gene sets across different PTB subgroups. (E) Line graph with scatter plot illustrating the percentage of samples in each time period from PTB exposure to greater than months, with clusters distinguished by color. (F) Venn diagram demonstrating the gene overlap among the three PTB subgroups. (G) Heatmap revealing the expression of selected over-expressed genes in PTB patients. The column annotation bar indicates the cluster to which each sample belongs. (H) Violin plot illustrating the expression of cytokine-related genes within the three PTB subgroups. (I) Bubble plot displaying enriched gene ontologies among the three PTB subgroups. Color change indicates the significance of enrichment, and the size of the points represents the number of genes in each GO term. (J) Bubble plot depicting enriched KEGG pathways among the three PTB subgroups. Color variation signifies the significance of enrichment, and the size of the points indicates the number of genes in each KEGG pathway.