Figure 3

Distribution of cell infiltration and expression patterns of gene sets related to PTB progression across Fges-derived subgroups. (A) Boxplot illustrating the distribution of cell infiltration estimated by the xCell tool across PTB subgroups. Not significant (ns): p > 0.05; *p < 0.01; **p < 0.001; ***p < 0.0001; ****p < 0.00001. P-values were obtained through t-test. (B) Boxplot displaying the infiltration of 22 immune cell types in PTB subgroups, as estimated by CIBERSORT. Not significant (ns): p > 0.05; *p < 0.01; **p < 0.001; ***p < 0.0001; ****p < 0.00001. P-values were obtained through t-test. (C) Bubble plot depicting the expression of Type I IFN and IFN-gamma pathway-related genes among PTB subgroups. The size of each point represents the percentage of samples expressing that gene, while the color reflects the variation in gene expression among the subgroups. (D) Bubble plot illustrating the expression of genes related to the positive regulation of hemopoiesis among PTB subgroups. The size of each point indicates the percentage of samples expressing that gene, and the color denotes the variation in gene expression across clusters. (E) Bubble plot demonstrating the expression of genes related to the response to reactive oxygen species and oxidative stress among PTB subgroups. The size of each point corresponds to the percentage of samples expressing that gene, while the color represents the variation in gene expression across clusters. (F) Bubble plot displaying the expression of Toll-like receptor and chemokine pathway-related genes among PTB subgroups. The size of each point indicates the percentage of samples expressing that gene, and the color signifies the variation in gene expression among the subgroups.