Table 2 Characteristic/findings of three PTB subgroups.
From: Multi-cohort analysis reveals immune subtypes and predictive biomarkers in tuberculosis
Characteristic/findings | Subgroup C1 | Subgroup C2 | Subgroup C3 |
|---|---|---|---|
Association with disease progression | Gradual increase during recovery phase | Gradual increase during recovery phase | Prevalent during outbreak phase |
Functional characteristics | ATP synthesis | Receptor degradation, amino sugar and nucleotide sugar metabolism | Cytokine-mediated signaling related to anti-inflammatory processes |
Immune-inflammatory activity | Low | Moderate | High |
Activity levels of cytokines | |||
Type I IFN and IFN-γ pathway activity | |||
Positive regulation of hemopoiesis pathway | |||
Toll-like receptor (TLR) and chemokine pathways | |||
CD8 + T cell abundance | High | Moderate | Low |
Macrophage cell abundance | Low | Moderate | High |
Enhanced MHC signaling | Low | Low | High |
