Figure 3
From: Flavivirus Zika NS4A protein forms large oligomers in liposomes and in mild detergent
Sedimentation equilibrium of ZIKV NS4A. (A) Sedimentation profile (circles) for NS4A loaded from high (left) to low (right) NS4A concentrations (see “Methods” section). The fitted line corresponding to the best fit 2–6 model (see B) is hidden below the data points. Fitting residuals in the lower panel show a small amplitude and random distribution; (B) Chi-squared values corresponding to several oligomerization models tested (shown in the x-axis). Best fit model (2–6) is shown in yellow. (C) Species population plot for the 2–6 model, with the concentration range present in SV and SE experiments indicated by dotted and grey areas, respectively.
