Table 3 Missense and silent mutations in samples categorized by the presence of driver mutations in EGFR and KRAS genes.
Sample type | Number of samples | Number of missense mutations | Number of silent mutations | Density missense (per sample, per site) | Density silent (per sample, per site) | dN/dS |
|---|---|---|---|---|---|---|
Driver mutations in EGFR | 69 | 14,700 | 6035 | 2.88E-06 | 3.86E-06 | 0.75 ± 0.03 |
No driver mutations in EGFR | 2362 | 855,254 | 291,208 | 4.89E-06 | 5.44E-06 | 0.89 ± 0.01 |
Driver mutations in KRAS | 160 | 80,537 | 24,213 | 6.80E-06 | 6.68E-06 | 1.02 ± 0.02 |
No driver mutations in KRAS | 2271 | 789,200 | 272,442 | 4.69E-06 | 5.30E-06 | 0.89 ± 0.01 |
