Figure 2

Irreversible stochastic model of cell division, death and forward differentiation for an ordered sequence of compartments. Grey cells represent death events. Self-renewal events occur with per-cell rate \(\lambda_i\), symmetric division events with rate \(s_i\), and asymmetric division events with rate \(a_i\). Differentiation events happen with per-cell rate \(\nu_i\). Death events have (per-cell) rate \(\mu_i\). Each per-cell rate is a real positive number.