Table 2 Significant numerical features distinguishing top 10% subgroup cases from all other cases for each disease.
From: Identifying and characterizing disease subpopulations that most benefit from polygenic risk scores
Disease | Data modality | Feature | Top 10% subgroup cases mean | All other cases mean | Cohen’s d | p-value |
|---|---|---|---|---|---|---|
CAD | Physical measurements | Systolic blood pressure | 143.47 ± 18.12 mmHg | 148.44 ± 19.35 mmHg | − 0.27 | 2.09 × 10−16 |
Hip circumference | 103.08 ± 8.56 cm | 104.74 ± 9.34 cm | − 0.19 | 5.61 × 10−9 | ||
BMI | 28.07 ± 4.39 kg/m2 | 28.80 ± 4.84 kg/m2 | − 0.16 | 4.87 × 10−7 | ||
Waist circumference | 94.06 ± 12.09 cm | 96.06 ± 13.52 cm | − 0.16 | 6.86 × 10−7 | ||
Lab results | Apolipoprotein B | 1.13 ± 0.27 g/L | 1.06 ± 0.25 g/L | 0.26 | 2.08 × 10−14 | |
LDL direct | 3.81 ± 0.99 mmol/L | 3.60 ± 0.93 mmol/L | 0.22 | 3.78 × 10−11 | ||
Triglycerides | 2.27 ± 1.23 mmol/L | 2.01 ± 1.08 mmol/L | 0.22 | 2.26 × 10 − 10 | ||
Cholesterol | 5.93 ± 1.31 mmol/L | 5.67 ± 1.23 mmol/L | 0.20 | 1.54 × 10−9 | ||
Direct bilirubin | 1.74 ± 0.61 μmol/L | 1.86 ± 1.07 μmol/L | − 0.14 | 1.09 × 10−7 | ||
BC | Physical measurements | Waist circumference | 83.47 ± 11.13 cm | 86.33 ± 12.51 cm | − 0.24 | 9.85 × 10−8 |
BMI | 26.48 ± 4.71 kg/m2 | 27.66 ± 5.18 kg/m2 | − 0.24 | 1.65 × 10−7 | ||
Hip circumference | 102.39 ± 9.23 cm | 104.64 ± 10.40 cm | − 0.23 | 3.95 × 10−7 | ||
Lab results | Urate | 263.78 ± 59.11 μmol/L | 278.63 ± 66.42 μmol/L | − 0.24 | 1.84 × 10−7 | |
Demographics | Age | 56.21 ± 7.60 years | 57.98 ± 7.60 years | − 0.23 | 9.14 × 10−7 | |
SZ | Lab results | Testosterone | 8.28 ± 5.70 nmol/L | 5.52 ± 5.24 nmol/L | 0.51† | 6.15 × 10−12 |
Urate | 329.24 ± 91.25 μmol/L | 297.14 ± 74.76 μmol/L | 0.39 | 2.99 × 10−7 | ||
Demographics | Age | 51.78 ± 7.71 years | 54.86 ± 8.25 years | − 0.39 | 1.95 × 10−8 |
