Table 2 Hemodynamic parameters at rest (after leg raise) and peak exercise.

From: Exercise pulmonary hypertension in patients with systemic sclerosis based on updated guidelines

 

Non-PH (n = 21)

Ex-PH (n = 19)

Overt-PH (n = 18)

p value

Non-PH vs Overt-PH

Non-PH vs Ex-PH

Ex-PH vs Overt-PH

Rest after leg raise

 HR, bpm

72 ± 14

71 ± 14

76 ± 10

0.523

   

 Systolic PAP, mmHg

29 ± 6

35 ± 7

48 ± 8

 < 0.001

 < 0.001

0.036

 < 0.001

 Diastolic PAP, mmHg

8 ± 3

8 ± 4

14 ± 4

 < 0.001

 < 0.001

1.000

 < 0.001

 Mean PAP, mmHg

18 ± 4

21 ± 6

29 ± 4

 < 0.001

 < 0.001

0.058

 < 0.001

 PAWP, mmHg

8 (7–13)

9 (7–13)

10 (7–13)

0.993

   

 Cardiac output, L/min

4.6 (3.8–6.0)

5.2 (4.0–6.2)

6.4 (5.1–8.9)

0.012

0.016

1.000

0.079

 PVR, Wood units

2.0 ± 1.4

2.4 ± 1.1

3.1 ± 1.1

0.025

0.021

0.890

0.275

 PAC, mL/mmHg

3.1 (2.0–5.2)

2.5 (2.2–3.7)

2.7 (2.4–3.0)

0.593

   

 C(a-v)O2, mL/dL

4.4 ± 0.7

4.3 ± 1.1

3.7 ± 0.7

0.027

0.029

1.000

0.137

 SaO2, %

98 (96–98)

97 (96–98)

95 (92–97)

0.002

0.002

0.675

0.096

 SvO2, %

70 ± 5

70 ± 6

72 ± 5

0.641

   

 VO2, mL/min

204 ± 68

216 ± 51

250 ± 47

0.046

0.048

1.000

0.226

 VCO2, mL/min

175 ± 59

179 ± 40

218 ± 52

0.022

0.033

1.000

0.072

 R

0.85 ± 0.06

0.83 ± 0.08

0.83 ± 0.09

0.867

   

 VE, L/min

7.8 ± 2.3

7.7 ± 1.5

10.4 ± 2.3

 < 0.001

0.001

1.000

0.001

 VE/VO2

38.6 (34.9–40.9)

38.1 (30.9–40.7)

42.3 (34.9–50.2)

0.163

   

 VE/VCO2

46.9 (39.8–51.7)

42.3 (39.2–49.7)

50.1 (42.4–61.5)

0.179

   

Peak

 Work rate, W

64 ± 21

48 ± 20

48 ± 22

0.027

0.065

0.061

1.000

 HR, bpm

114 ± 26

109 ± 19

108 ± 21

0.709

   

 Systolic PAP, mmHg

49 ± 10

60 ± 11

70 ± 12

 < 0.001

 < 0.001

0.005

0.018

 Diastolic PAP, mmHg

13 ± 4

18 ± 7

19 ± 8

0.014

0.020

0.062

1.000

 Mean PAP, mmHg

29 ± 6

38 ± 7

44 ± 8

 < 0.001

 < 0.001

 < 0.001

0.034

 PAWP, mmHg

16 (10–21)

18 (16–22)

16 (10–18)

0.261

   

 Cardiac output, L/min

9.9 (9.1–12.6)

8.3 (6.7–11.0)

9.6 (8.2–11.6)

0.303

   

 PVR, Wood units

1.1 (0.8–1.6)

2.3 (2.0–3.1)

3.0 (2.1–4.2)

 < 0.001

 < 0.001

 < 0.001

0.498

 PAC, mL/mmHg

2.7 (2.1–3.4)

2.1 (1.7–2.4)

1.9 (1.6–2.1)

0.004

0.006

0.041

1.000

 C (a-v) O2, mL/dL

8.2 ± 1.5

7.6 ± 1.7

6.7 ± 1.3

0.017

0.014

0.743

0.253

 SaO2, %

96 (95–98)

95 (93–96)

92 (89–95)

0.002

0.002

0.146

0.146

 SvO2, %

46 ± 8

49 ± 9

51 ± 7

0.199

   

 VO2, mL/min

850 (656–1096)

673 (509–772)

685 (603–794)

0.057

   

 VCO2, mL/min

924 (635–1240)

684 (540–880)

756 (613–810)

0.164

   

 R

1.07 ± 0.18

1.10 ± 0.13

1.06 ± 0.13

0.722

   

 VE, L/min

27.8 (24.5–39.3)

27.6 (21.4–30.4)

33.2 (29.6–39.3)

0.053

   

 VE/VO2

38.5 (32.4–42.2)

41.9 (32.4–49.1)

50.9 (44.4–58.2)

0.009

0.004

0.873

0.242

 VE/VCO2

37.0 ± 8.2

40.0 ± 11.0

48.6 ± 9.3

0.001

0.001

0.981

0.024

 Peak VO2, mL/kg/min

14.5 (12.0–20.3)

13.0 (9.8–15.6)

12.5 (10.1–13.7)

0.043

0.123

0.082

1.000

 VE vs. VCO2 slope

32.2 (27.3–34.1)

32.4 (26.7–37.4)

43.0 (34.8–50.7)

0.003

0.002

1.000

0.044

  1. Values are reported as mean ± standard deviation or medians (interquartile ranges).
  2. C (a-v) O2 arteriovenous O2 difference, ex-PH exercise pulmonary hypertension, HR heart rate, PAC pulmonary arterial compliance, PAP pulmonary arterial pressure, PAWP pulmonary arterial wedge pressure, PH pulmonary hypertension, PVR pulmonary vascular resistance, SaO2 O2 saturation in arterial blood, SvO2 O2 saturation in the pulmonary artery, VO2 oxygen consumption, VCO2 carbon dioxide output, R respiratory exchange ratio, VE minute ventilation.
Back to article page