Figure 3

Single exposure–response functions plot of BKMR model for urine metal mixture exposure in total population (A) and diabetics (C), and blood metal mixture exposure in total population (B) and diabetics (D). Fix other metals at the 50th percentile to assess the exposure effects of a single metal. Model A adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no), blood glucose state (diabetics, pre-diabetics, non-diabetics) and urine Cd, Mn, Pb, Hg. Model B adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no), blood glucose state (diabetics, pre-diabetics, non-diabetics) and blood Cd, Mn, Pb, Hg. Model C adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no) and urine Cd, Mn, Pb, Hg. Model D adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no) and blood Cd, Mn, Pb, Hg.