Figure 4

Overall effect plot of BKMR model for urine metal mixture exposure in total population (A) and diabetics (C), and blood metal mixture exposure in total population (B) and diabetics (D). The metal mixture was fixed at the 50th percentile as a reference and gradually increased from the 25th percentile to the 75th percentile to compare the changes in probability. Model A adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no), blood glucose state (diabetics, pre-diabetics, non-diabetics) and urine Cd, Mn, Pb, Hg. Model B adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no), blood glucose state (diabetics, pre-diabetics, non-diabetics) and blood Cd, Mn, Pb, Hg. Model C adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no) and urine Cd, Mn, Pb, Hg. Model D adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no) and blood Cd, Mn, Pb, Hg.