Figure 6

Interaction plot of BKMR model for urine metal mixture exposure in total population (A) and diabetics (C), and blood metal mixture exposure in total population (B) and diabetics (D). A metal was fixed at a specific percentile to compare the difference of effects on CKD when another single metal rising one interquartile range, while remaining metals were fixed in their median values. Abbreviations: UCd, urine cadmium; UMn, urine manganese; UPb, urine lead; UHg, urine mercury; BCd, blood cadmium; BMn, blood manganese; BPb, blood lead; BHg, blood mercury. Model A adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no), blood glucose state (diabetics, pre-diabetics, non-diabetics) and urine Cd, Mn, Pb, Hg. Model B adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no), blood glucose state (diabetics, pre-diabetics, non-diabetics) and blood Cd, Mn, Pb, Hg. Model C adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no) and urine Cd, Mn, Pb, Hg. Model D adjusted for age (20–39,40–59, 60–80 years old), hypertension (yes, no), cardiovascular disease (yes, no), cancer (yes, no) and blood Cd, Mn, Pb, Hg.