Table 3 R_obs/pre ratios of brivaracetam PK parameters for healthy population via oral route.

Administered dose (mg)	C_max (µg/ml)			AUC_0–∞ (µg h/ml)			CL (ml/min/kg)			References
Administered dose (mg)	Obs	Pre	R-value	Obs	Pre	R-value	Obs	Pre	R-value	References
Intravenous administration profile
100 mg/ml	3.796	4.065	0.93	31.421	19.524	1.6	3.182	6.121	0.62	21
Oral administration profile
10	0.20	0.20	0.97	2.58	2.59	0.99	3.86	3.85	1.0	21
50	1.10	1.06	1.04	16.27	13.15	1.2	3.07	3.80	0.8	21
75	1.74	1.602	1.08	23.48	20.32	1.15	3.19	3.68	0.86	21
100	2.19	2.14	1.025	32.75	27.0	1.2	3.05	3.69	0.82	21
200	3.632	3.26	1.1	47.2	28.04	1.6	4.23	7.13	0.59	22
100	2.244	1.885	1.19	29.6	19.70	1.5	3.375	5.07	0.66	23
10	0.20	0.16	1.25	2.45	1.443	1.69	4.076	6.928	0.58	13
20	0.35	0.33	1.07	3.87	3.269	1.18	5.159	6.117	0.84	13
40	0.7554	0.665	1.13	9.322	6.884	1.35	4.290	5.810	0.73	13
80	1.888	1.339	1.4	17.83	13.8	1.29	4.085	5.794	0.77	13
150	3.336	2.529	1.3	42.77	26.78	1.59	3.506	5.599	0.62	13
300	6.285	5.169	1.2	76.53	55.99	1.36	3.919	5.357	0.731	13
600	13.971	10.64	1.3	152.20	125.87	1.20	3.941	4.766	0.82	13
1000	23.147	18.19	1.27	279.08	236.04	1.18	3.583	4.236	0.84	13
1400	34.50	26.04	1.32	417.79	372.2	1.12	3.350	3.760	0.89	13
2.5	0.067	0.038	1.7	0.876	0.90	0.97	2.85	2.77	1.02	24
10	0.34	0.22	1.5	3.542	3.63	0.975	2.82	2.22	1.27	24
25	0.76	0.52	1.46	7.306	8.9	0.82	3.42	2.90	1.17	24
50	1.263	1.0	1.2	17.51	17.27	1.01	2.85	2.79	1.02	24
100	2.09	2.09	1.0	31.85	30.30	1.05	3.13	3.3	0.94	24
2.5	0.03	0.05	0.6	26.31	25.90	1.01	0.09	0.07	1.3	24
10	0.14	0.22	0.63	54.51	53.51	1.02	3.8	3.85	0.98	24
50	0.72	0.61	1.18	153.09	152.9	1.0	3.81	3.85	0.98	24

Obs observed, Pre predicted, C_max maximum systemic concentration, CL clearance, AUC_0–∞ area under the curve from time 0 to ∞, H healthy.

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