Table 5 Robs/pre ratios of brivaracetam PK parameters for liver cirrhosis after oral administration.

From: Investigating clinical pharmacokinetics of brivaracetam by using a pharmacokinetic modeling approach

Dose (mg)

Population

Cmax (µg/ml)

AUC0–∞ (µg h/ml)

CL (ml/min/kg)

Reference

Obs

Pre

R-value

Obs

Pre

R-value

Obs

Pre

R-value

100

CP-A

2.2369

1.840

1.2

44.51

43.0

1.0

2.398

2.312

1.03

23

CP-B

3.062

1.916

1.5

42.50

39.12

1.1

2.207

2.510

0.9

CP-C

2.541

1.597

1.6

46.30

36.90

1.25

2.167

2.910

0.74

  1. Obs observed, Pre predicted, Cmax maximum systemic concentration, CL clearance, AUC0–∞ area under the curve from time 0 to ∞, CP Child–Pugh.
Back to article page