Table 1 Demographics and clinical characteristics of the XDP patients.

From: Motor assessment of X-linked dystonia parkinsonism via machine-learning-based analysis of wearable sensor data

#

Age at assessment (yr)

Age at onset (yr)

BFM

MDS-UPDRS Part 3

Phenotype

Dystonia

Dystonia features

Parkinsonism

Parkinsonism features

1

38

35

24

17

DP

Y

Cervical, Oromandibular, SD, Tongue, Blepharospasm, Trunk

Y

Hypomimia, Hypophonia, Bradykinesia, Gait

2

62

34

9

27

DP Park

Y

Oromandibular, SD

Y

Hypomimia, Hypophonia, Bradykinesia, Gait, Freezing, Postural instability

3

53

47

43.5

48

DP

Y

Cervical, Oromandibular, SD, Trunk, UE, LE, Gait

Y

Hypomimia, Hypophonia, Bradykinesia, Resting tremor, Gait, Postural instability

4

50

44

7.5

42

DP

Y

Cervical, Oromandibular

Y

Hypomimia, Hypophonia, Bradykinesia, Gait, Freezing, Postural instability

5

67

55

12

38

DP Park

Y

Cervical, Oromandibular, SD

Y

Hypomimia, Hypophonia, Bradykinesia, Gait, Freezing, Postural instability

6

62

44

10.5

38

DP Park

Y

Cervical, SD, Tongue

Y

Hypomimia, Hypophonia, Bradykinesia, Gait, Freezing, Postural instability

7

61

51

0

31

Park only

N

 

Y

Hypomimia, Hypophonia, Bradykinesia, Gait, Freezing, Postural instability

8

45

41

12.5

13

DP Dyst

Y

Cervical, Oromandibular, LE

Y

Hypomimia, Hypophonia, Bradykinesia, Gait

9

48

42

23.5

15

DP Dyst

Y

Cervical, Oromandibular, Blepharospasm, LE

Y

Hypomimia, Hypophonia, Bradykinesia, Gait, Postural instability

10

54

32

2

17

DP Park

Y

LE

Y

Hypomimia, Hypophonia, Bradykinesia, Gait

  1. DP, dystonia parkinsonism; DP Dyst, Dystonia parkinsonism with predominant dystonia; DP Park, Dystonia parkinsonism with predominant parkinsonism; Park only, Parkinsonism as sole phenotype; Dyst only, Dystonia as sole phenotype; SD, Spasmodic dysphonia; UE, Upper extremity; LE, Lower extremity.
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