Figure 7 | Scientific Reports

Figure 7

From: MARK4 aggravates cardiac dysfunction in mice with STZ-induced diabetic cardiomyopathy by regulating ACSL4-mediated myocardial lipid metabolism

Figure 7

Expression of ACSL4 in vivo and in vitro in STZ-induced DCM models and the effect of ACSL4 deficiency on lipid metabolism in STZ-induced DCM models. (A, B) The expression of the ACSL4 protein in STZ-induced diabetic cardiomyopathy mice (n = 6 samples per group). (C, D) The expression of the ACSL4 protein in cardiomyocytes treated with high-glucose and high-lipid (n = 6 samples per group). (E–I) Western blot and quantitative analysis of the levels of fatty acid oxidation-related proteins (CPT1A, CPT2, and PPAR-α) following ACSL4 knockdown in STZ-induced DCM mice (n = 4 samples per group). (J, K) Changes in the expression of the ACSL4 protein in each group (n = 6 samples per group). (L–O) Western blot and quantitative analysis of the levels of fatty acid oxidation-related proteins following ACSL4 knockdown in DCM cardiomyocytes (n = 6 samples per group). The data are presented as the means ± SDs. Significant differences are indicated by *P < 0.05, **P < 0.01, and ***P < 0.001.

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