Table 2 Results of the statistical analysis on the electrophysiological data from Pavlovian conditioned approach baseline and reward omission session on sign-tracking rats.

I. OFC and NAc neuronal population activity (mean firing rate of all recorded neurons) during baseline session
OFC NAc
Variable		MWU (U)	P			MWU (U)	P
CS onset		1298	0.05			729	0.65
CS offset		1253	0.02			647	0.21
RE after CS offset		1537	0.53			653	0.23
II. OFC and NAc neuronal population activity (mean firing rate of all recorded neurons) during omission session
CS onset		1436	0.04			680	0.53
CS offset		1719	0.56			676	0.50
RE after CS offset		1697	0.49			738	0.96
III. Mixed-linear model (MLM) analysis comparing the possible influences of OFC neuronal firing rate after CS onset and lever presses 10 before CS offset
Session Baseline Omission
	F			P	F			P
Exposure	9.176			0.003	0.002			0.963
LP 10 s before CS onset × firing rate	4.250			0.042	0.000			0.991
Interaction	6.062			0.015	2.427			0.122
IV. OFC individual neuronal firing rate and subsequent rat behavioral response: correlational slope comparison between control and AIE group
Session Baseline Omission
	T-test (t)			P	T-test (t)			P
CS onset and LP 10 s before CS offset	2.65			0.009	0.40			0.68
CS offset and RE 10 s before CS offset	5.07			< 0.001	0.21			0.82

Group comparisons on OFC and NAc population neuronal activity were conducted using Mann–Whitney U test. Analyses on OFC population activity across baseline and omission sessions were carried out using generalized linear model with a Poisson distribution and a log link function. Underlined type indicates significant differences (p values are described on the table). Bold underlined type indicates significant differences (see methods). CS (conditional stimulus); LP (lever presses); NAc (nucleus accumbens); OFC (orbitofrontal cortex); RE (receptacle entries).

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