Figure 3 | Scientific Reports

Figure 3

From: Combined oral low-dose cyclophosphamide endocrine therapy may improve clinical response among patients with metastatic breast cancer via Tregs in TLSs

Figure 3

The presence of TLSs and the number of Tregs in TLSs before treatment affect prognosis. (A) Patients who received TLS pretreatment had a more favorable prognosis. (B) H&E staining was used to observe TLSs. (C) The number of TLSs in patients with different prognoses. (D) The presence of TLSs significantly differed in patients with different prognoses. (E) The presence of Treg cells in TLSs and peripheral blood was positively correlated. (F) The number of Tregs in TLSs before treatment affected prognosis. (G) The difference in the number of Treg cells among TLSs was evaluated by multicolor immunofluorescence staining. (H) Patients with higher numbers of Tregs in TLSs had longer PFS after low-dose CY + ET treatment.

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