Table 1 Baseline characteristics of study participants by the systemic immune-inflammation index (SII) quartile in NHANES 2007–2016.

From: L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

Characteristic

SII levels

p value

Quartile 1 (≤ 343.63)

Quartile 2 (343.63–460)

Quartile 3 (460–645.65)

Quartile 4 (> 645.65)

Age (%)

0.013

 40–59

65.05

65.38

66.21

64.93

 

 60–69

22.59

33.97

20.79

20.83

 

 70–79

12.36

11.66

13.00

14.24

 

Gender (%)

 < 0.001

 Men

52.02

50.38

47.34

44.88

 

 Women

47.98

49.62

52.66

55.12

 

Race (%)

 < 0.001

 Mexican American

6.11

7.64

6.61

5.85

 

 Other Hispanic

4.51

4.36

3.85

3.68

 

 Non-Hispanic White

66.92

74.22

76.23

79.11

 

 Non-Hispanic Black

17.36

9.29

7.57

6.06

 

 Other Race—Including Multi-Racial

5.11

4.49

5.74

5.30

 

Education level (%)

 < 0.001

 Less than 9th grade

7.00

7.85

7.88

6.79

 

 9–11th grade

12.76

9.72

12.51

14.28

 

 High school graduate/GED or equivalent

24.04

25.11

23.03

24.40

 

 Some college or AA degree

27.20

28.67

27.82

28.33

 

 College graduate or above

29.01

28.92

28.76

26.19

 

Marital status (%)

 < 0.001

 Married

65.76

70.88

67.33

63.98

 

 Widowed

5.65

5.27

6.49

7.14

 

 Divorced

13.67

12.33

13.80

14.78

 

 Separated

2.34

2.16

2.27

3.21

 

 Never married

8.01

4.89

6.08

7.12

 

 Living with partner

4.58

4.47

4.03

3.77

 

Smoking (%)

0.006

 ≥ 100 cigarettes in life

47.67

48.34

50.01

51.62

 

 < 100 cigarettes in life

52.33

51.66

49.99

48.38

 

Alcohol (%)

 < 0.001

 ≥ 12 drinks/year

69.50

70.73

73.68

68.04

 

 < 12 drinks/year

30.50

29.27

26.32

31.96

 

Diabetes (%)

 < 0.001

 Yes

11.55

10.76

10.75

14.21

 

 No

88.45

89.24

89.25

85.79

 

Hypertension (%)

0.003

 Yes

39.64

40.08

39.27

43.17

 

 No

60.36

59.92

60.73

56.83

 

Body mass index (kg/m2)

28.47 ± 5.77

29.34 ± 6.20

29.09 ± 6.17

29.83 ± 7.27

 < 0.001

Neutrophils count (103/μL)

2.90 ± 0.97

3.67 ± 0.96

4.34 ± 1.14

5.58 ± 1.74

 < 0.001

Lymphocyte count (103/μL)

2.40 ± 1.06

2.20 ± 0.68

2.04 ± 0.62

1.81 ± 0.60

 < 0.001

Platelet count (103/μL)

205.79 ± 50.33

237.82 ± 51.32

257.83 ± 52.88

297.99 ± 74.53

 < 0.001

Neutrophil to lymphocyte ratio

1.28 ± 0.38

1.72 ± 0.38

2.21 ± 0.50

3.29 ± 1.26

 < 0.001

Klotho (pg/ml)

885.70 ± 335.79

853.04 ± 303.99

846.06 ± 276.3

813.35 ± 272.22

 < 0.001

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