Table 2 Association between immune-inflammation index (SII) and serum anti-aging protein klotho.

From: L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

 

β (95% CI), p value

Crude model

Minimally adjusted model

Fully adjusted model

(Model 1)

(Model 2)

(Model 3)

Continuous

 − 0.08 (− 0.10, − 0.07)

 < 0.001

 − 0.08 (− 0.10, − 0.07)

 < 0.001

 − 0.07 (− 0.08, − 0.05)

 < 0.001

Quartile 1

Reference

Reference

Reference

SII quartile

 Quartile 2

 − 34.44 (− 49.06, − 19.82)

 < 0.001

 − 30.37 (− 44.97, − 15.77)

 < 0.001

 − 30.39 (− 45.28, − 15.50)

0.179

 Quartile 3

 − 55.44 (− 70.06, − 40.82)

 < 0.001

 − 50.40 (− 65.05, − 35.74)

 < 0.001

 − 48.76 (− 63.73, − 33.79)

 < 0.001

 Quartile 4

 − 78.78 (− 93.40, − 64.16)

 < 0.001

 − 70.62 (− 85.38, − 55.86)

 < 0.001

 − 67.65 (− 82.84, − 52.45)

 < 0.0001

 p for trend

 < 0.001

 < 0.001

 < 0.001

  1. All estimated results were expressed as β (95% CI); β, Partial regression coefficient; CI, Confidence interval.
  2. Model 1: Covariates were not adjusted at all.
  3. Model 2: Adjusted for gender, age, and race.
  4. Model 3: Adjusted for gender, age, race, marital status, education level, smoking status, alcohol, diabetes and hypertension.
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