Table 3 Threshold effect analysis for the relationship between immune-inflammation index (SII) and serum anti-aging protein klotho in NHANES 2007–2016.

From: L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

Model

Serum klotho protein concentration Adjusted β (95% CI), p value

Fitting by standard linear model

 − 0.07 (− 0.08, − 0.05), < 0.001

Fitting by two-piecewise linear model

 Breakpoint (K)

255

 β1 (< K)

 − 1.08 (− 1.30, − 0.87), < 0.001

 β2 (> K)

 − 0.04 (− 0.06, − 0.03), < 0.001

 β2/β1

1.04 (0.82, 1.26), < 0.001

 Logarithmic likelihood ratio test p value

 < 0.001

  1. Adjusted for gender, age, race, marital status, education level, smoking status, alcohol, diabetes and hypertension.
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