Figure 11 | Scientific Reports

Figure 11

From: X-ray imageable, drug-loaded hydrogel that forms at body temperature for image-guided, needle-based locoregional drug delivery

Figure 11Figure 11

Comparison of cone beam CT (CBCT), optical imaging of DOX, and DOX drug mapping following injection of 4 mL POL22 with iodine and DOX, 20 μg/mL. Three devices were used: SEHN, MSHN, and MPIN. Three procedures were used for the MPIN: MPIN-1cm; MPIN deployed 2 cm and retracted during injection (technique 2); and, MPIN deployed 5 cm and retracted during injection (technique 5). (a–d, column 1) Circularity of optical imaging of DOX on the cut surface of the bovine liver compared to iodine on corresponding multiplanar reformatted sections on CBCT. (a–d) Relative concentration of DOX in µg/mL over the diameter for three infusions (column 2, minor axis; column 3, major axis). (e–i) Gross section (column 1), multiplanar reformatted sections on CBCT (column 2), DOX fluorescence intensity with optical imaging (column 3), and drug mapping (column 4). ns, not significant. Error bars represent standard deviations of mean value. n = 3 for all the experiments.

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