Table 2 Characteristics of included studies.

From: Comparative study of safflower yellow adjuvant to conventional treatment regimen and conventional treatment regimen on diabetic nephropathy

Study ID	Age		Sample size		The dosage regimen		Course	Evaluation indicator
Study ID	Treatment group	Control group	Treatment group	Control group	Treatment group	Control group	Course	Evaluation indicator
Xuemei Bai 2012¹⁹	55.8 ± 7.6	56.0 ± 7.9	30	30	CT + SY 200 mg	CT	30d	①②
Xijing Bao 2017²⁰	49.74 ± 7.03	50.45 ± 7.12	40	40	CT + Metformin hydrochloride 2 g + SY 100 mg	CT + Metformin hydrochloride 2 g	14d	①⑤
Yan Gao 2015²¹	65.0 ± 5.8	64.6 ± 5.7	60	60	CT + Benazepril 10 mg + SY 100 mg	CT + Benazepril 10 mg	28d	①③④⑤
Zhi Li 2012²²	61.3	61.3	30	30	CT + Losartan potassium 50 mg + SY100mg	CT + Losartan potassium 50 mg	15d	⑤
Jingjing Liu 2019²³	56.72 ± 6.03	57.36 ± 5.87	55	55	CT + Metformin 5 mg + SY100mg	CT + Metformin 5 mg	21d	①③④
Xiang Fang 2017²⁴	65.3 ± 12.8	66.4 ± 11.5	52	50	CT + SY 150 mg	CT	14d	②③④⑤
Tianlin Qiu 2013²⁵	52.7 ± 7.1	51.6 ± 6.6	44	42	CT + Valsartan 80 mg + SY 100 mg	CT + Valsartan 80 mg	30d	⑤
Yiming Wang 2017²⁶	51.18 ± 12.67	50.66 ± 11.27	60	60	CT + Metformin 4.0 g + SY 100 mg	CT + Metformin 4.0 g	14d	①⑤
Lijun Duan 2017²⁷	55.21 ± 4.35	55.21 ± 4.35	60	60	Alprostadil injection 10 μg + SY 100 mg	Alprostadil injection 10 μg	14d	⑤
Yongli Feng 2016²⁸	53.7 ± 7.1	50.6 ± 6.6	30	30	CT + SY and sodium chloride injection100 ml + Xylitol injection 150 ml + Shenmai injection 50 ml	CT + SY and sodium chloride injection100 ml	14d	⑤
Yuxia Xiao 2016²⁹	59.5 ± 12.4	58.9 ± 13.2	40	40	CT + SY injection 100 ml	CT	28d	②⑤
Yan Gao 2015³⁰	51.13 ± 7.42	51.13 ± 7.42	44	44	CT + Telmisartan tablets 80 mg + SY 100 mg	CT + Telmisartan tablets 80 mg	28d	③④
Hailiang Yu 2014³¹	40 ~ 76	40 ~ 76	36	32	CT + SY 100 mg	CT + Compound salvia miltiorrhiza 20 ml	14d	②③
Zhenfu Fang 2015³²	55.8 ± 7.6	56.0 ± 7.9	45	45	CT + Valsartan 80 mg + SY injection 100 ml	CT + Valsartan 80 mg	56d	②⑤
Shengkai Wu 2019³³	54.24 ± 2.91	54.24 ± 2.91	50	50	CT + SY injection 20 ml	CT	28d	①
Rui Xie 2018³⁴	56.1 ± 8.4	55.1 ± 8.0	34	34	CT + Sulodexide 3 pills + SY 100 mg	CT + Sulodexide 3 pills	21d	①③④
Tongdao Xu 2014³⁵	36.8 ± 14.2	36.8 ± 14.2	18	18	CT + Pancreatic kininogenase + SY injection 100 ml	CT + Pancreatic kininogenase	21d	①②⑤
Shufeng Yan 2015³⁶	45.6 ± 4.6	45.3 ± 4.5	36	36	CT + Valsartan 80 mg + SY 100 mg	CT + Valsartan 80 mg	30d	①②③④
Bikui Yang 2011³⁷	59 ± 7.7	59 ± 7.7	38	34	CT + SY 100 mg	CT + Compound salvia miltiorrhiza 20 ml	14d	②③
Xingshun Yang 2007³⁸	53.4 ± 5.4	53.5 ± 5.6	24	24	CT + Safflower yellow 80 mg	CT + Salvia miltiorrhiza 20 ml	28d	①
Xiaoping Yang 2012³⁹	66	66	34	33	SY 100 mg + alpha-lipoic acid 600 mg	Conventional western medicine treatment	15d	①②
Siyu Jiao 2012⁴⁰	58	56	30	30	CT + SY injection ( Acupoint injection therapy, 2 ml per acupuncture point)	CT	30d	⑤
Meilan Yin 2018⁴¹	55.89 ± 5.20	56.44 ± 5.20	52	53	CT + SY 100 mg	CT	14d	①②③④
Yong Guo 2010⁴²	48 ± 11.6	48 ± 11.6	42	39	CT + SY 100 mg	CT + Danhong injection 20 ml	14d	②③
Lihua Yang 2010⁴³	58.6	58.3	30	30	CT + SY 100 mg	CT	14d	①②⑤
Dengzhou Guo 2008⁴⁴	47.3 ± 12.6	46.9 ± 13.2	39	37	CT + Benazepril 10 mg + SY 150 mg	CT + Benazepril 10 mg	30d	②⑤
Xiangying Zhang 2010⁴⁵	48 ~ 80	46 ~ 78	36	36	CT + Irbesartan150mg + SY 100 mg	CT + Irbesartan150mg	28d	①②③④
Zhaoming Shi 2015⁴⁶	48	48	45	45	CT + Valsartan 80 mg/d + SY 150 mg	CT + Valsartan 80 mg/d	84d	②

SY, Safflower yellow; CT, Conventional treatment; d, day; ① = FBG, Fasting blood-glucose; ② = UAER, Urinary albumin excretion rate; ③ = Scr, Serum creatinine; ④ = BUN, Blood urea nitrogen; ⑤ = Clinical efficacy.

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Table 2 Characteristics of included studies.

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