Figure 4
From: Primary oocytes with cellular senescence features are involved in ovarian aging in mice
Comparative transcriptome profiling of mouse ovaries during aging and between the ovaries of ABT263-treated mice and control mice. (A–D) Gene ontology analysis of biological pathways (BP) that were significantly upregulated in the ovaries of 6-month-old mice (A) and 9-month-old mice (B) compared with 3-month-old mice; and the BPs that were significantly downregulated in the ovaries of 6-month-old mice (C) and 9-month-old mice (D) compared with 3-month-old mice. (E, F) BPs that were significantly upregulated (E) or downregulated (F) in 6-month-old ovaries of ABT263-treated mice compared with that of control mice. (G, H) BPs that were significantly upregulated (G) or downregulated (H) in 9-month-old ovaries of ABT263-treated mice compared with that of control mice. (I) Heatmap showing fold change in mRNA expression of SASP factors in mouse ovaries during aging and between the ovaries of ABT263-treated mice and control mice. n = 3 mice at each time point were used for RNA extraction and sequencing.
