Table 1 Differences in the studied parameters between the non-PM and PM groups.

From: Differences between pathologic and non-pathologic high myopia in 4-year outcomes of anti-VEGF therapy for macular neovascularization

  

Non-PM group

PM group

P-value

Eyes, n

 

19

99

 

Age at baseline, years

 

63.4 ± 9.6

66.9 ± 9.8

0.09

AL at baseline, mm

 

28.53 ± 0.94

29.49 ± 1.73

0.03*

Male sex, n (%)

 

1 (5)

26 (26)

0.046*

LogMAR BCVA

Baseline

0.29 ± 0.34

0.52 ± 0.39

0.02*

 

1-year

0.12 ± 0.22

0.37 ± 0.40

0.01*

 

2-year

0.20 ± 0.33

0.40 ± 0.43

0.02*

 

3-year

0.28 ± 0.38

0.41 ± 0.42

0.10

 

4-year

0.28 ± 0.36

0.46 ± 0.41

0.07

MNV location at baseline (extrafoveal/juxtafoveal/subfoveal), n

 

6/0/13

23/20/56

0.67

MNV size at baseline, mm2

 

0.42 ± 0.49

0.57 ± 0.65

0.52

CRT at baseline, μm

 

288.9 ± 107.3

291.1 ± 153.5

0.82

CCT at baseline, μm

 

74.2 ± 36.7

57.9 ± 22.3

0.06

Number of injections, n

1st year (0–1 year)

2. 9 ± 1.3

1.9 ± 1.2

0.002*

 

2nd year (1–2 years)

0.9 ± 1.1

0.5 ± 1.0

0.02*

 

3rd year (2–3 years)

0.6 ± 1.0

0.2 ± 0.7

0.002*

 

4th year (3–4 years)

0.2 ± 0.5

0.2 ± 0.6

0.97

 

Total (0–4 years)

4.6 ± 2.6

2.9 ± 2.6

0.001*

Ratio of IVR against the total number of injections

 

0.70 ± 0.45

0.59 ± 0.45

0.18

No additional treatment, n (%)

 

3 (16)

35 (35)

0.095

ERM, n (%)

Baseline

2 (11)

20 (20)

0.32

 

4-year

3 (16)

31 (31)

0.17

LMH, n (%)

Baseline

0 (0)

0 (0)

 

4-year

0 (0)

3 (3)

0.44

Lens status, n (phakia/pseudophakia/aphakia)

Baseline

14/5/0

67/31/1

0.82

 

4-year

11/8/0

43/55/1

0.48

  1. Data are presented as means ± standard deviations where applicable.
  2. PM = pathologic myopia; logMAR BCVA = logarithm of the minimal angle of resolution best-corrected visual acuity; AL = axial length; MNV = macular neovascularization; CRT = central retinal thickness; CCT = central choroidal thickness; IVR = intravitreal injection of ranibizumab; ERM = epiretinal membrane; LMH = lamellar macular hole.
  3. *, Statistically significant (P < 0.05).
  4. , Chi-square test; , chi-square trend test; for the others, the Mann–Whitney U test was used.