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Figure 2

From: Antimicrobial peptide 2K4L inhibits the inflammatory response in macrophages and Caenorhabditis elegans and protects against LPS-induced septic shock in mice

Figure 2

2K4L inhibits the inflammatory response in infected THP-1 cells. (A–D) Effect of 2K4L (1, 2 and 4 h) on the production of TNF-α (A,C) and IL-6 (B,D) by ELISA in THP-1 cells infected with MRAB 0227 (A,B) and AB 22933 (C,D) for 4 h. (E–J) Western blotting analysis of the effects of 2K4L on the expression of p-NF-κB (E,F), p-IκB (E,G), total-NF-κB (H,I) and total-IκB (H,J) after the cells were infected with MRAB 0227 for 4 h and incubated with or without peptides for 1, 2 and 4 h. #(P < 0.05) and ##(P < 0.01) indicate statistically significant differences between the MRAB 0227/AB 22933 group and control (0.9% NaCl). PMB-treated MRAB 0227/AB 22933 group for 4 h as a positive control. *(P < 0.05) and **(P < 0.01) indicate statistically significant differences between the peptide and MRAB 0227/AB 22933 groups.

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