Table 3 The top 16 pathways (p ≤ 0.05) enriched and ranked in the Mummichog pathway analysis in MetaboAnalyst.

From: Untargeted metabolomics reveal signatures of a healthy lifestyle

Pathway name

Pathway totala

Hits.totalb

cHits.sigc

FETd

Bile acid biosynthesis

82

50

42

0.000

Histidine metabolism

33

12

11

0.003

Lysine metabolism

52

15

15

0.005

Heparan sulfate degradation

34

3

3

0.006

Phytanic acid peroxisomal oxidation

34

5

5

0.006

Glycosphingolipid metabolism

67

15

13

0.009

Pyrimidine metabolism

70

19

16

0.011

Chondroitin sulfate degradation

37

3

3

0.015

N-Glycan Degradation

16

6

6

0.020

Aminosugars metabolism

69

8

8

0.025

Beta-Alanine metabolism

20

8

8

0.025

Vitamin D3 (cholecalciferol) metabolism

16

13

10

0.033

Glycosphingolipid biosynthesis—ganglioseries

62

4

4

0.034

Glycosphingolipid biosynthesis—globoseries

16

2

2

0.034

Butanoate metabolism

34

17

14

0.044

Tyrosine metabolism

160

63

48

0.047

  1. aPathway total indicates the overall number of metabolites that are included in a specific pathway.
  2. bHits.total indicates the number of measured signals that are matched (m/z error < 3 ppm) with the metabolites included in the pathway.
  3. cHits.sig indicates the number of matched signals that were significantly changed between phenotypic groups.
  4. dFET is the right-tail p-value determined by the Fisher Exact Test for pathway enrichment.
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